The San Francisco 49ers are also dealing with a litany of injuries. In addition to Christian McCaffrey and Deebo Samuel both ...

San Francisco 49ers running back Christian McCaffrey will be eligible off the injured reserve after Week 6, but could still miss a pivotal Week 7 Super Bowl rematch with the Kansas City Chiefs.

The San Francisco 49ers will likely be without All-Pro tight end George Kittle for Sunday's game against the Los Angeles Rams ...

With Christian McCaffrey already on the injured reserve, Deebo Samuel has been ruled out due to injury for Week 3 in Los ...

Two of the best wide receivers in the NFL are expected to be on the field for their respective Week 3 games. Justin Jefferson ...

George Kittle, Deebo Samuel, and Christian McCaffrey have all scored multiple touchdowns in the 49ers’ recent visits to SoFi ...

San Francisco 49ers star tight end George Kittle is doubtful for Sunday's game at the Los Angeles Rams due to a hamstring ...

In a segment on "The Insiders", NFL Network insider Ian Rapoport: Herbert's ankle injury will make Bolts QB's Week 3 status a 'coaching decision' ...

San Francisco 49ers' George Kittle is listed as doubtful for Sunday's game against the Rams. He joins Christian McCaffrey and ...

The 49ers need a backup running back. That's why they traded up for Isaac Guerendo in Round 4 this year. Just in case someone gets injured. And currently, both ...

The 49ers are likely to be without George Kittle, Christian McCaffrey and Deebo Samuel for Sunday's game at the Rams.

Speaking to NBC Sports Bay Area's Greg Papa on "49ers Game Plan," Kyle Shanahan explained why the offense won't change ...