The San Francisco 49ers can't catch a break in their offensive backfield. It started in training camp when running back ...

The San Francisco 49ers are going to have a fourth different starting running back this season according to a report from ...

San Francisco 49ers running back Isaac Guerendo appeared on Wednesday's injury report due to a hamstring issue sustained ...

Isaac Guerendo was initially uncertain for Thursday night, but the rookie looks like he might give it a go. Here's the latest ...

The San Francisco 49ers have been decimated by injuries all year, specifically at the running back position. Christian ...

Coach Kyle Shanahan said Monday that the 49ers expect Guerendo (foot/hamstring) to practice Thursday, Nick Wagoner of ESPN.com reports.

Curious to know about 49ers RB Isaac Guerendo‘s injury? The standout rookie has drawn attention for his breakout performances ...

Well this isn't good. 49ers rookie Isaac Guerendo is nursing a new injury. Kyle Shanahan revealed Guerendo was held out of ...

ESPN insider Adam Schefter reported that San Francisco 49ers rookie running back Isaac Guerendo is unlikely to play against ...

The 49ers won’t be down to their 4th-string running back tonight against the Rams as Isaac Guerendo is expected to play ...

San Francisco 49ers running back Isaac Guerendo. / Bob Kupbens-Imagn Images The San Francisco 49ers are already down Jordan Mason and Christian McCaffrey in their backfield (both are on injured ...

“49ers rookie RB Isaac Guerendo plans to play Thursday night vs. the Rams despite his sprained foot that has left him being ...